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• 大阳城集团99aa 药物中间体或其它化学品业务服务内容
  设计具有知识产权和成本优势的中间体合成路线工艺路线筛选，工艺的优化，质量研究，工艺安全评估 放大生产（GMP或者非GMP） 分析方法的开发和验证提供精细化工品的合成路线开发、工艺优化，以及放大生产服务， 特别是一些高附加值精细化工品的工艺开发和生产。

• 医药中间体的合成技术
  定向硝化技术高温高压反应技术缩合技术控制氧化技术氟化技术加氢还原技术不对称合成不对称催化反应如生物催化

• 大阳城集团99aa 的医药中间体研发能力与水平
  引进、设计和研究医药中间体产品技术商业化路线的筛选通过反应设计（DoE）和质量设计（QbD）进行商业化工艺的开发与优化 单元操作研究和各步骤关键工艺参数的确认 杂质的结构，来源以及控制的研究 GMP起始原料的界定 迅速取得医药中间体小试结果，承接中试放大任务，为工业化生产提供可靠的工艺依据具备医药中间体的结构分析和性能测试的能力。

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  大阳城集团99aa PROTAC中间体产品列表

  Number	Compound Name	Purity	Inventory
  1	3-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride	97.4	500 mg
  2	3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride	94.6	1.6 g
  3	1-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide hydrochloride	94.4	1.3 g
  4	t-Boc-N-amido-PEG5-acid	97	/
  5	t-Boc-N-amido-PEG1-acid	\	\
  6	Pomalidomide	99.8	\
  7	2-(2,6-dioxopiperidin-3-yl)-5-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione	90	9.5 g
  8	2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid	90	102 mg
  9	perfluorophenyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate	90	23 mg
  10	1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidine-4-carbaldehyde	90	100 mg
  11	2-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	90	200 mg
  12	1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde	90	100 mg
  13	2-(2,6-dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione	96.4	102.08 mg
  14	2-(2,6-dioxopiperidin-3-yl)-4-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione	94.8	101.91 mg
  15	1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylic acid	97.7	104.5 mg
  16	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride	98.3	103 mg
  17	2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride	92.46	101 mg
  18	2-(2,6-dioxopiperidin-3-yl)-5-[4-(hydroxymethyl)-3-methylpiperidin-1-yl]isoindole-1,3-dione	95.1	103 mg
  19	2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione	97.8	102 mg
  20	QL12003-700-1	95.7	26 mg
  21	QL12003-707-2	93.9	28 mg
  22	QL12003-707-1	99.7	20 mg
  23	QL12003-667-3	62	20 mg
  24	QL12003-667-1	99.4	27 mg
  25	QL12003-650-1	63.2	28 mg
  26	inter14-10		90 mg
  27	QLS12010-1058-4		20mg
  28	QLS12003-697-3		27.61mg
  29	QL-MDC1001-3		2.342 g
  30	QL-MDC1001-4		1.680 g
  31	QLS12003-504-5		2.02 g
  32	QLS12003-605-1	96.3	240 mg
  33	QLS12003-605-2	99.2	65 mg
  34	QLS12003-605-3	88.7	60 mg
  35	QLS12003- inter14	86.7	50 mg
  36	QLS12003- inter1-7		65 mg
  37	QLS12003- 563-7		30 mg
  38	QLS12003-693-2		85 mg
  39	QLS12003-696-2	93.7	54 mg
  40	QLS12003-609-2	82	110 mg
  41	tert-butyl 4-(2-((1s,3s)-3-(benzyloxy)cyclobutoxy)ethyl)piperazine-1-carboxylate	95	2.05 g
  42	tert-butyl (3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)(methyl)carbamate	98	213 mg
  43	tert-butyl 3-(prop-2-yn-1-yloxy)propanoate	95	0.66 g
  44	tert-butyl 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanoate	95	1.33 g
  45	tert-butyl 4-(2-((1s,3s)-3-((methylsulfonyl)oxy)cyclobutoxy)ethyl)piperazine-1-carboxylate	95	167 mg
  46	tert-butyl (2-(3-hydroxypropoxy)ethyl)carbamate	95	1.45 g
  47	5-(4-((1,4-dioxaspiro[4.5]decan-8-yl)methyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione	99	2.83 g
  48	2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((4-oxocyclohexyl)methyl)piperazin-1-yl)isoindoline-1,3-dione	95	740 mg
  49	3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid	95	430 mg
  50	tert-butyl 3-(2-(2-(2-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoate	95	760 mg
  51	3-(2-(2-(2-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid	90	430 mg
  52	3-(4-(3-(3-hydroxypropoxy)propyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione	90	200 mg
  53	3-(3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propoxy)propyl methanesulfonate	92	100 mg
  54	4-((4,4-dimethoxybutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	97	868 mg
  55	ethyl 1-(3-cyanophenyl)piperidine-4-carboxylate	85	1.68 g
  56	ethyl 1-(4-cyanophenyl)piperidine-4-carboxylate	99	14.4 g
  57	methyl 1-(7-hydroxyheptyl)-1H-indole-6-carboxylate	87	520 mg
  58	1-(7-hydroxyheptyl)-1H-indole-6-carboxylic acid	96	335 mg
  59	methyl 1-(7-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)heptyl)-1H-indole-6-carboxylate	95	138 mg
  60	tert-butyl 4-(2-((1s,3s)-3-hydroxycyclobutoxy)ethyl)piperazine-1-carboxylate	85	300 mg
  61	6-bromo-7-methoxy-2-methylquinazolin-4-ol	88.4	60.0 mg
  62	methyl 5-amino-2H-indazole-6-carboxylate	94	60.0 mg
  63	tert-butyl 9-((methylsulfonyl)oxy)-3-azaspiro[5.5]undecane-3-carboxylate	90	60.0 mg
  64	benzyl 4-(tosyloxy)piperidine-1-carboxylate	95	60.0 mg
  65	N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.6	60.0 mg
  66	tert-butyl 4-(3-(4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidin-1-yl)propyl)piperidine-1-carboxylate	86.5	60.0 mg
  67	tert-butyl 4-(3-(tosyloxy)propyl)piperidine-1-carboxylate	93	60.0 mg
  68	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-ethoxybenzoate	93	60.0 mg
  69	(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethan-1-amine	98	100.0 mg
  70	(R)-1-(2-fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine	98	100.0 mg
  71	(R)-1-(3-nitro-5-(trifluoromethyl)phenyl)ethan-1-amine	94	100.0 mg
  72	2-amino-5-bromo-4-methoxybenzamide	97	100.0 mg
  73	(R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethan-1-amine	95	100.0 mg
  74	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione	98	310 mg
  75	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoate	92	120 mg
  76	3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid	97	115 mg
  77	N-(2-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	96	50 mg
  78	tert-butyl ((1r,4r)-4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)cyclohexyl)carbamate	80	110 mg
  79	5-(4-(2,2-dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	93	100 mg
  80	2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione	100	170 mg
  81	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-morpholinobenzoate	96	110 mg
  82	N-(2-((1r,4r)-4-((3-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3-azaspiro[5.5]undecan-9-yl)(ethyl)amino)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	98.3	20 mg
  83	5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-chloro-1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	100	75 mg
  84	N-(2-(1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	100	180 mg
  85	tert-butyl 4-((1S,4s)-4-(4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)cyclohexane-1-carbonyl)piperazine-1-carboxylate	91	100 mg
  86	N-(2-((1r,4r)-4-formylcyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	97.64	105 mg
  87	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoate	90.86	115 mg
  88	N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.47	152 mg
  89	5-hydroxy-3-(2-(hydroxymethyl)-1H-indol-3-yl)isoindolin-1-one	97.13	116 mg
  90	tert-butyl 4-(6-(difluoromethoxy)-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidine-1-carboxylate	97.46	106 mg
  91	tert-butyl 9-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)-3-azaspiro[5.5]undecane-3-carboxylate	97.85	110 mg
  92	tert-butyl 9-(4-(6-methoxy-5-nitro-2H-indazol-2-yl)cyclohexyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate	96.89	60 mg
  93	N-(2-(1-(2-(3-azaspiro[5.5]undecan-9-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	98.12	139 mg
  94	N-(2-((1r,4r)-4-formylcyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.15	81 mg
  95	benzyl 2-(2-(tosyloxy)ethyl)-7-azaspiro[3.5]nonane-7-carboxylate	91.63	146 mg
  96	3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indole-2-carbaldehyde	90	58 mg
  97	tert-butyl 4-((3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indol-2-yl)methyl)piperazine-1-carboxylate	80.83	107 mg
  98	N-(6-methoxy-2-((1r,4r)-4-((methylamino)methyl)cyclohexyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	95.91	103 mg
  99	tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate	95	237 mg
  100	2A-1	96.05	1.3 g+300 mg
  101	Pomalidomide-C6-CO2H	99.38	60 mg
  102	Pomalidomide-C2-NH2 hydrochloride	98.81	244 mg
  103	Pomalidomide-C3-NH2 hydrochloride	99.6	220 mg
  104	Pomalidomide-C6-NH2 hydrochloride	99.27	185 mg
  105	Pomalidomide-C7-NH2 hydrochloride	99.36	130 mg
  106	Pomalidomide-C2-CO2H	95.83	380 mg
  107	B-2	95.9	460 mg
  108	Pomalidomide-C5-CO2H	95.19	500 mg
  109	2A-4	99.31	1.26 g
  110	Pomalidomide-C9-CO2H	98.86	50 mg
  111	B-9	97.19	100 mg
  112	B-8	96.06	400 mg
  113	B-10	96.12	160 mg
  114	2A-2	96.61	150 mg
  115	Pomalidomide-PEG2-NH2 hydrochloride	97.95	400 mg
  116	Pomalidomide-PEG1-NH2 hydrochloride	96.34	468 mg
  117	2A-5	98.22	168 mg
  118	Pomalidomide-C8-NH2 hydrochloride	99.18	150 mg
  119	5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	97.1	185 mg
  120	4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	98.6	441 mg
  121	5-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99.9	50 mg
  122	4-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	95.4	52 mg
  123	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99	1.547 g
  124	2-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	90	3.5 g
  125	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione	90	155 mg
  126	1-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde	90	167 mg
  127	5-(4-(hydroxymethyl)piperidin-1-yl)-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99	164 mg
  128	2-(2,6-dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)azetidin-1-yl)isoindoline-1,3-dione	98	200 mg
  129	2-(2,6-dioxopiperidin-3-yl)-4-(4-((4-hydroxypiperidin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione	99	134 mg
  130	2-(2,6-dioxopiperidin-3-yl)-5-(3-hydroxyazetidin-1-yl)isoindoline-1,3-dione	100	101 mg
  131	2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoacetaldehyde	86	59 mg
  132	5-(4-((4-(((R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pyrrolidin-1-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	100	83 mg
  133	2-(2,6-dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	96	100 mg
  134	2-(2,6-dioxopiperidin-3-yl)-5-(9-oxo-3-azaspiro[5.5]undecan-3-yl)isoindoline-1,3-dione	96	187 mg

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